二氧化碳点阵激光治疗单侧唇裂术后瘢痕的疗效观察

doi:10.19438/j.cjoms.2026.04.012

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (4): 396-400.doi: 10.19438/j.cjoms.2026.04.012

二氧化碳点阵激光治疗单侧唇裂术后瘢痕的疗效观察

迟浩姝¹, 沈玲悦², 解嘉慧³, 吴玉波^1,*, 蔡鸣^3,*

1.上海市徐汇区口腔医院口腔颌面外科, 口腔生物材料与组织再生实验室, 上海 200030;
2.上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,激光美容科,上海交通大学口腔医学院, 国家口腔医学中心,口腔疾病国家临床医学研究中心,上海市口腔医学重点实验室, 上海市口腔医学研究所,上海 200011;
3.上海交通大学医学院附属第九人民医院口腔颅颌面科, 上海交通大学口腔医学院,国家口腔医学中心, 口腔疾病国家临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2025-11-05 修回日期:2026-02-09 发布日期:2026-08-05
通讯作者: 吴玉波,E-mail: echomand@hotmail.com;蔡鸣,E-mail: zidanecm500@126.com。^*共同通信作者
作者简介:迟浩姝（1996—）,女,硕士研究生,E-mail: chs07162021@126.com

Observation on therapeutic effect of carbon dioxide fractional laser on scar after unilateral cleft lip operation

Chi Haoshu¹, Shen Lingyue², Xie Jiahui³, Wu Yubo¹, Cai Ming³

1. Department of Oral and Maxillofacial Surgery, Laboratory of Dental Biomaterials and Tissue Regeneration, Shanghai Xuhui District Stomatological Hospital. Shanghai 200032;
2. Department of Oromaxillofacial Head and Neck Oncology & Department of Laser Cosmetology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine;College of Stomatology, Shanghai Jiao Tong University;National Center for Stomatology;National Clinical Research Center for Oral Diseases;Shanghai Key Laboratory of Stomatology;Shanghai Research Institute of Stomatology. Shanghai 200011;
3. Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine;College of Stomatology, Shanghai Jiao Tong University;National Center for Stomatology;National Clinical Research Center for Oral Diseases;Shanghai Key Laboratory of Stomatology;Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2025-11-05 Revised:2026-02-09 Published:2026-08-05

摘要/Abstract

摘要： 目的：探讨二氧化碳（CO₂）点阵激光在单侧唇裂一期修复术后瘢痕治疗中的效果,为唇裂术后瘢痕的防治提供一种可靠且有效的新途径。方法：选取2023年3月—2024年3月于上海交通大学医学院附属第九人民医院行一期单侧唇裂修复术的患者36例,随机分为试验组与对照组,每组各18例。试验组术后1个月接受CO₂点阵激光治疗,并联合硅酮凝胶涂抹及按摩治疗;对照组仅采用硅酮凝胶涂抹及按摩治疗。术后1年采用温哥华瘢痕量表（Vancouver Scar Scale, VSS）对瘢痕恢复情况进行客观评价。结果：术后1年,两组患者瘢痕均较治疗前明显改善（P<0.001）;试验组VSS总分（1.72±0.18）显著低于对照组（3.94±0.27）,且在瘢痕厚度和硬度方面的改善更为显著（P<0.001）;两组在瘢痕色泽和血管分布方面的差异无统计学意义（P>0.05）,但试验组均值更低,存在临床改善潜力。所有患者治疗期间均未出现明显不良反应。结论：CO₂点阵激光联合硅酮凝胶及按摩治疗,可有效改善单侧唇裂一期术后瘢痕的形态与质地,值得临床推广和应用。

关键词: 二氧化碳点阵激光, 唇裂, 温哥华瘢痕评分, 瘢痕治疗

Abstract: PURPOSE: To investigate the clinical efficacy of carbon dioxide (CO₂) fractional laser in the treatment of post-operative scars following cleft lip repair. METHODS: A total of 36 patients who underwent primary repair of unilateral cleft lip at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from March 2023 to March 2024 were randomly divided into the experimental group (n=18) and the control group (n=18). The experimental group received CO₂ fractional laser treatment 1 month after surgery combined with silicone gel application and massage therapy; the control group only received silicone gel application and massage therapy. One year postoperatively, the Vancouver Scar Scale (VSS) was used to objectively evaluate scar recovery. RESULTS: One year after surgery, the scars of patients in both groups were significantly improved compared with those before treatment (P<0.001); the total VSS score of the experimental group (1.72±0.18) was significantly lower than that of the control group (3.94±0.27), and the improvements in scar thickness and hardness were more significant (P<0.001); there were no statistically significant differences between the two groups in color and vascular distribution (P>0.05), but the mean values of the experimental group were lower, showing potential clinical improvement. No obvious adverse reactions occurred in all patients during treatment. CONCLUSIONS: CO₂ fractional laser treatment effectively improves the morphology and texture of scars following cleft lip repair, making it worthy of clinical promotion and application.

Key words: Carbon dioxide fractional laser, Cleft lip, Vancouver scar scale, Scar treatment

中图分类号:

R782.2

迟浩姝, 沈玲悦, 解嘉慧, 吴玉波, 蔡鸣. 二氧化碳点阵激光治疗单侧唇裂术后瘢痕的疗效观察[J]. 中国口腔颌面外科杂志, 2026, 24(4): 396-400.

Chi Haoshu, Shen Lingyue, Xie Jiahui, Wu Yubo, Cai Ming. Observation on therapeutic effect of carbon dioxide fractional laser on scar after unilateral cleft lip operation[J]. China J Oral Maxillofac Surg, 2026, 24(4): 396-400.

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二氧化碳点阵激光治疗单侧唇裂术后瘢痕的疗效观察

Observation on therapeutic effect of carbon dioxide fractional laser on scar after unilateral cleft lip operation

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