钛网+膜联合使用修复种植体周围牙槽骨缺损的实验研究

doi:10.19438/j.cjoms.2017.02.006

中国口腔颌面外科杂志 ›› 2017, Vol. 15 ›› Issue (2): 127-130.doi: 10.19438/j.cjoms.2017.02.006

钛网+膜联合使用修复种植体周围牙槽骨缺损的实验研究

李慧萍^*, 孙守福^*, 甄锦泽, 王烨欣, 徐伟峰, 郑吉驷, 张善勇, 朱应超, 钟晓琪

上海交通大学医学院附属第九人民医院·口腔医学院口腔外科, 上海市口腔医学重点实验室,上海 200011

收稿日期:2016-09-26 出版日期:2017-03-20 发布日期:2017-04-13
通讯作者: 张善勇,E-mail: zhangshanyong@126.com;郑吉驷,E-mail: 237111641@qq.com。^#并列通信作者
作者简介:李慧萍（1992-）,女,硕士研究生,E-mail:lhp1992122@163.com;孙守福（1990-）,男,硕士,住院医师,E-mail：sunshoufu@163.com。*并列第一作者

Guided bone regeneration and simultaneous implant placement using membrane in combination with titanium mesh for repair of alveolar defects in Beagle dogs

LI Hui-ping, SUN Shou-fu, ZHEN Jin-ze, WANG Ye-xin, XU Wei-feng, ZHENG Ji-si, ZHANG Shan-yong, ZHU Ying-chao, ZHONG Xiao-qi

Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine;
Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2016-09-26 Online:2017-03-20 Published:2017-04-13
Contact: 上海市科学技术委员会西医引导类项目（134119a5400）; 浦东新区联合攻关项目（PW2016D-1）; 上海交通大学医学院研究生处课程建设项目; 上海交通大学医学院大学生创新训练项目（2016508）

摘要/Abstract

摘要： 目的探讨联合使用钛网+Bio-Gide膜修复比格犬种植体周围牙槽骨缺损的效果。方法选择3只成年比格犬,拔除双侧下颌P1-M1,牙槽窝愈合6个月。将3只比格犬（共6侧）随机分为3组,A组使用种植体+骨粉+钛网,B组使用种植体+骨粉+Bio-Gide膜,C组使用种植体+骨粉+钛网+Bio-Gide膜。每侧选取3个位点制备种植窝,在颊侧制作4 mm×4 mm×4 mm牙槽骨缺损,植入种植体并分别覆盖钛网或Bio-Gide膜。于术后6个月处死动物并取材,Micro-CT扫描并三维重建。使用SPSS17.0软件包对测量结果进行统计学分析。结果 Micro-CT扫描及三维重建结果显示,C组的骨小梁数目、骨小梁厚度、骨密度等数据显著高于另外两组（P<0.01）,骨小梁分散度显著低于另外两组（P<0.01）。结论联合使用钛网+Bio-Gide膜,对比格犬种植体周围牙槽骨缺损的修复作用显著优于单纯使用钛网或Bio-Gide膜。

关键词: 引导性骨再生术, 钛网, 牙槽骨缺损, 牙种植, 比格犬

Abstract: PURPOSE : To evaluate the effect of using guided bone regeneration (GBR) with (titanium) Ti mesh and Bio-Gide membrane in repair of alveolar bone defects in Beagle dogs. METHODS : Three mandibular premolars and one molar on both sides of the jaw in 3 dogs were extracted. Six months after extraction, three implants were inserted into each side, and alveolar bone defects (4 mm×4 mm×4 mm in size) were produced. 24 implants in total 6 sides were assigned to 3 groups and covered with different membranes as follows, group A: implant+Bio-Oss+Ti-mesh; group B: implant+Bio-Oss+Bio-Gide, group C: implant+Bio-Oss+Ti-mesh+Bio-Gide. The claps were sutured over the membranes to complete the wound closure. The animals were sacrificed after 6 months, and non-decalcified histological specimens of the implants and surrounding tissues were prepared. Micro-CT scanning was carried out to test the results. SPSS17.0 software package was used for statistical analysis. RESULTS : Micro-CT with three-dimensional reconstruction revealed that bone regeneration in group C was significantly better than the other two groups (P<0.01), which indicated faster new bone deposition. CONCLUSION S: Combination of Bio-Gide membrane and Ti-mesh may get a better bone regeneration than Ti-mesh or Bio-Gide used alone.

Key words: Guided bone regeneration, Titanium mesh, Alveolar defects, Tooth implant, Beagle dogs

中图分类号:

R782.1

李慧萍, 孙守福, 甄锦泽, 王烨欣, 徐伟峰, 郑吉驷, 张善勇, 朱应超, 钟晓琪. 钛网+膜联合使用修复种植体周围牙槽骨缺损的实验研究[J]. 中国口腔颌面外科杂志, 2017, 15(2): 127-130.

LI Hui-ping, SUN Shou-fu, ZHEN Jin-ze, WANG Ye-xin, XU Wei-feng, ZHENG Ji-si, ZHANG Shan-yong, ZHU Ying-chao, ZHONG Xiao-qi. Guided bone regeneration and simultaneous implant placement using membrane in combination with titanium mesh for repair of alveolar defects in Beagle dogs[J]. China J Oral Maxillofac Surg, 2017, 15(2): 127-130.

参考文献

[1] Shimono K, Oshima M, Arakawa H, et al. The effect of growth factors for bone augmentation to enable dental implant placement: a systematic review [J]. Jpn Dent Sci Rev, 2010, 46(1): 43-53.
[2] Hämmerle CH, Karring T. Guided bone regeneration at oral implant sites [J]. Periodontol 2000, 1998, 17:151-175.
[3] Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry[J]. Int J Oral Maxillofac Implants, 2009, 24(Suppl): 237-259.
[4] Baek YJ, Kim JH, Song JM, et al. Chitin-fibroin-hydroxyapatite membrane for guided bone regeneration: micro-computed tomography evaluation in a rat model[J]. Maxillofac Plast Reconstr Surg, 2016, 38(1): 14.
[5] Yoo CK, Jeon JY, Kim YJ, et al. Cell attachment and proliferation of osteoblast-like MG63 cells on silk fibroin membrane for guided bone regeneration[J]. Maxillofac Plast Reconstr Surg, 2016, 38(1): 17.
[6] Hämmerle CH, Jung RE, Feloutzis A. A systematic review of the survival of implants in bone sites augmented with barrier membranes (guided bone regeneration) in partially edentulous patients [J]. J Clin Periodontol, 2002, 29 (Suppl 3): 226-231.
[7] Jeyaraj P. Efficacy and versatility of the 3-D titanium mesh implant in the closure of large post-craniectomy osseous defects, and its therapeutic role in reversing the syndrome of the trephined: clinical study of a case series and review of literature[J]. J Maxillofac Oral Surg, 2016, 15(1): 82-92.
[8] Buser D, Dahlin C, Schenk RK. Guided bone regeneration in implant dentistry [J]. J Dent, 1995, 23(6):378-378.
[9] Bottino MC, Thomas V, Schmidt G, et al. Recent advances in the development of GTR/GBR membranes for periodontal regeneration- a materials perspective [J]. Dent Mater, 2012, 28(7): 703-721.
[10] Levine RA, McAllister BS. Implant site development using Ti-mesh and cellular allograft in the esthetic zone for restorative-driven implant placement: a case report [J]. Int J Periodontics Restorative Dent, 2016, 36(3): 373-381.
[11] Van Steenberghe D, Johansson C, Quirynen M, et al. Bone augmentation by means of a stiff occlusive titanium barrier [J]. Clin Oral Implants Res, 2003, 14(1): 63-71.
[12] Fugazzotto PA. Success and failure rates of osseointegrated implants in function in regenerated bone for 6 to 51 months: a preliminary report [J]. Int J Oral Maxillofac Implants, 1997, 12(1): 17-24.

[1]	孙思敏, 张森林. 动态导航引导下下颌骨缺损腓骨瓣移植修复区种植体植入1例报告[J]. 中国口腔颌面外科杂志, 2024, 22(5): 513-517.
[2]	王敬夫, 张宁, 杨勇, 张巍瀚, 常欣. 69例中老年人群切牙管形态学特征的CBCT测量分析[J]. 中国口腔颌面外科杂志, 2024, 22(4): 385-389.
[3]	张佳园, 于德栋, 冀敏, 林海燕. 3D打印自就位钛网的仿真分析及实验研究[J]. 中国口腔颌面外科杂志, 2023, 21(5): 432-438.
[4]	王荷静, 张采欣, 寻兴祥, 韩林孜, 闫婷婷, 许晓, 袁荣涛. 骨替代材料在上颌窦底外提升同期牙种植中的作用探讨[J]. 中国口腔颌面外科杂志, 2023, 21(3): 218-224.
[5]	王博, 于洪波, 夏韫晖, 房兵, 郭秋曼. 牙槽骨再生正畸技术治疗成人错畸形伴原发性牙槽骨缺损的远期疗效评价[J]. 中国口腔颌面外科杂志, 2022, 20(3): 225-229.
[6]	李慧萍, 刘秀明, 徐伟峰, 甄锦泽, 沈达, 张善勇. 环肌酸抑制大鼠牙周炎周围牙槽骨吸收的实验研究[J]. 中国口腔颌面外科杂志, 2022, 20(2): 111-116.
[7]	马捷, 王齐帅, 张兵华, 陈天天, 蔡国平, 宋涛. 口腔种植体-基台微间隙充填对种植修复系统及周围骨力学的影响[J]. 中国口腔颌面外科杂志, 2022, 20(2): 117-122.
[8]	费晨艳, 江银华. 生长因子在牙槽骨组织再生中的应用与研究进展[J]. 中国口腔颌面外科杂志, 2021, 19(6): 568-572.
[9]	徐晓峰, 朱方兴, 廖倩, 徐兵, 沈国芳, 张文斌, 史俊. 75例下颌骨粉碎性骨折的治疗效果评价[J]. 中国口腔颌面外科杂志, 2021, 19(5): 456-459.
[10]	杜福江, 何水明, 朱鹏娜. 个体化3D打印头颅模型辅助三维预成型钛网在6例复杂上颌骨骨折治疗中的应用[J]. 中国口腔颌面外科杂志, 2021, 19(4): 368-371.
[11]	张楚南, 赵旭, 乔士冲, 张晓梦, 顾迎新. 拔牙窝内植入不同深度骨水平种植体周围软硬组织改建的组织形态变化[J]. 中国口腔颌面外科杂志, 2021, 19(3): 193-196.
[12]	杨路鹏, 樊林峰, 史俊宇, 张枭, 顾迎新, 张楚南. 磨牙区使用角度螺丝一体冠不同全瓷材料修复种植单冠：1年前瞻性半口自身对照研究[J]. 中国口腔颌面外科杂志, 2021, 19(3): 222-225.
[13]	邹多宏, 刘昌奎, 薛洋, 胡开进, 杨驰, 张志愿. 帐篷钉技术在牙槽骨修复与再生中的临床应用及操作规范[J]. 中国口腔颌面外科杂志, 2021, 19(1): 1-5.
[14]	李成, 施乐. 2种修复膜材料用于牙种植引导骨再生的临床效果比较[J]. 中国口腔颌面外科杂志, 2020, 18(5): 438-441.
[15]	秦坤, 刘红红, 章润宇, 张志宏. 引导骨再生术对前牙区种植牙龈美学及牙槽骨吸收的影响[J]. 中国口腔颌面外科杂志, 2020, 18(3): 236-239.

钛网+膜联合使用修复种植体周围牙槽骨缺损的实验研究

Guided bone regeneration and simultaneous implant placement using membrane in combination with titanium mesh for repair of alveolar defects in Beagle dogs

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价