血管内皮细胞生长因子在颞下颌关节骨关节炎中的研究进展

中国口腔颌面外科杂志 ›› 2014, Vol. 12 ›› Issue (3): 277-280.

血管内皮细胞生长因子在颞下颌关节骨关节炎中的研究进展

徐伟峰, 张善勇

上海交通大学医学院附属第九人民医院·口腔医学院口腔外科,上海市口腔医学重点实验室,上海 200011

收稿日期:2013-11-14 出版日期:2014-05-10 发布日期:2014-07-15
通讯作者: 张善勇,Tel:021-63138341-52104,Fax:021-63136856,E-mail:zhangshanyong@126.com E-mail:xwf19891215@sina.com
作者简介:徐伟峰(1989-),男,在读硕士研究生
基金资助:
国家自然科学基金(81371168);上海市自然科学基金(10ZR1418200);上海市浦江人才计划;上海交通大学医学院“新百人计划”;上海交通大学医学院第七期大学生创新训练项目(2013052)

Advances in study of the role of vascular endothelial growth factor in the pathogenesis of temporomandibular joint osteoarthritis

XU Wei-feng, ZHANG Shan-yong

Department of Oral Surgery, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2013-11-14 Online:2014-05-10 Published:2014-07-15

摘要/Abstract

摘要： 颞下颌关节骨关节炎(temporomandibular joint osteoarthritis, TMJOA)是一种发病率高、危害大的常见颞下颌关节紊乱病,其主要病理过程包括软骨退变、滑膜炎和黏连形成。血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)是一种促进血管生长因子,近年来发现在TMJOA的关节盘、髁突软骨、滑膜组织及关节液中均有表达,故逐渐被认为是TMJOA形成的一种重要可疑因子。本文就VEGF在TMJOA发病过程中的作用及研究进展做一综述。

关键词: VEGF, 软骨退变, 黏连形成, 滑膜炎

Abstract: Temporomandibular joint osteoarthritis(TMJOA) is a very common disease of temporomandibular joint disorders, which has a high morbidity and results in unbearable sufferings for patients, such as limitation of mouth opening, pain in the TMJ and clicking. The main pathological processes of TMJOA included cartilage degeneration, synovitis and adhesion formation. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors, recently, studies have showed that VEGF was found in the articular disc, condylar cartilage, synovial tissue and synovial fluid in TMJOA, and it is increasingly considered to be an important suspicious factor in the formation of TMJOA. This review summarized the current literature on the studies of VEGF on TMJOA. Supported by National Natural Science Foundation of China (81371168), Natural Science Foundation of Shanghai Municipality (10ZR1418200), Shanghai Pujiang Talent Plan in 2011,The New Hundred Talents Program of Shanghai Jiao Tong University School of Medicine in 2011, The Seventh College Students Innovation Training Project of Shanghai Jiao Tong University School of Medicine (2013052).

Key words: VEGF, Cartilage degeneration, Adhesion formation, Synovitis

中图分类号:

R782.6

徐伟峰, 张善勇. 血管内皮细胞生长因子在颞下颌关节骨关节炎中的研究进展[J]. 中国口腔颌面外科杂志, 2014, 12(3): 277-280.

XU Wei-feng, ZHANG Shan-yong. Advances in study of the role of vascular endothelial growth factor in the pathogenesis of temporomandibular joint osteoarthritis[J]. China J Oral Maxillofac Surg, 2014, 12(3): 277-280.

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