中国口腔颌面外科杂志 ›› 2025, Vol. 23 ›› Issue (1): 77-83.doi: 10.19438/j.cjoms.2025.01.014

• 综述 • 上一篇    下一篇

淋巴显影结合淋巴管-静脉吻合术治疗淋巴管畸形的研究现状

于凡, 杜仲, 李顺顺, 游元和, 田卓炜, 肖孟, 王延安   

  1. 上海交通大学医学院附属第九人民医院 口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011
  • 收稿日期:2024-03-19 修回日期:2024-05-12 出版日期:2025-01-20 发布日期:2025-01-23
  • 通讯作者: 王延安,E-mail:yan.an.wang@sjtu.edu.cn
  • 作者简介:于凡(1997-),男,硕士,E-mail:medyufan@163.com
  • 基金资助:
    国家自然科学基金(81371164,81870780,82201085)

Current progress of lymphatic imaging combined with lymphatic-venous anastomosis in the treatment of lymphatic malformations

YU Fan, DU Zhong, LI Shun-shun, YOU Yuan-he, TIAN Zhuo-wei, XIAO Meng, WANG Yan-an   

  1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology. Shanghai 200011, China
  • Received:2024-03-19 Revised:2024-05-12 Online:2025-01-20 Published:2025-01-23

摘要: 淋巴管畸形(lymphatic malformation,LM)是一种先天性淋巴管发育畸形,大量淋巴液积聚在病变区域畸形扩张的淋巴管腔内,当患者的淋巴免疫反应增强时,即出现病变区域的肿痛及功能障碍,给患者带来极大痛苦。目前,针对LM的主要治疗手段包括硬化治疗、手术切除、靶向药物治疗等,但各种治疗方法均无法实现病变区域异常淋巴回流的长期恢复与重建。作为超显微外科技术的代表之一,淋巴管-静脉吻合术(lymphatic-venous anastomosis,LVA)可通过淋巴显影和显微镜的辅助,将病灶区域的淋巴管与周围静脉吻合重建,从而实现改善和重建局部淋巴引流的目标。目前,已有部分研究尝试在LM患者中开展此类手术,并获得了良好疗效,但尚未得到推广。本文结合最新国内外研究成果,从淋巴显影技术、基于淋巴显影的LM分型、LVA的发展与挑战、LVA治疗LM的研究及应用现状、LVA的围术期护理等方面进行综述,以期促进该技术在治疗LM领域的研究、应用及发展。

关键词: 淋巴管畸形, 淋巴显影, 淋巴管-静脉吻合术, 围术期护理

Abstract: Lymphatic malformation (LM) is a congenital malformation of lymphatic development in which a large amount of lymph fluids accumulating in the malformed and dilated lymphatic lumen of the lesions. When the lymphatic immune response of the patient is enhanced, the swelling and dysfunction of the lesion area will occur, which brings great pain to the patient. At present, the main treatment methods for LM include sclerotherapy, surgical resection, targeted drug therapy, etc. However, none of these treatment methods can achieve long-term recovery and reconstruction of abnormal lymphatic reflux in the lesion area. Lymphatic-venous anastomosis(LVA), as one of the representatives of supermicrosurgical techniques, can reconstruct the lymphatic vessels in the lesion area with the surrounding veins through lymphatic visualization and microscopy, so as to achieve the goal of improving and reconstructing the local lymphatic drainage. At present, some studies have attempted to perform such surgery in patients with LM and achieved good results, but it has not been widely promoted. Based on the latest research results both at home and abroad, this article reviewed lymphatic imaging technology, lymphatic imaging staging and classification of LM, surgical methods of LVA, research and application status of LVA in the treatment of LM, and perioperative nursing of LVA, in order to promote the research, application and development of this technology in the field of LM treatment.

Key words: Lymphatic malformation, Lymphatic angiography, Lymphatic-venous anastomosis, Perioperative nursing

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