左侧上颌骨牙源性影细胞癌1例报告及文献复习

doi:10.19438/j.cjoms.2024.06.017

中国口腔颌面外科杂志 ›› 2024, Vol. 22 ›› Issue (6): 618-621.doi: 10.19438/j.cjoms.2024.06.017

左侧上颌骨牙源性影细胞癌1例报告及文献复习

郭小冬^1,2, 苏勤军², 王环环^1,2, 何倩倩^1,2, 陈哲宇^2,3, 姬菩忠², 马迎春², 杨艳丽^1,2,3

1.甘肃中医药大学,甘肃兰州 730000;
2.中国人民解放军联勤保障部队第940医院病理科,甘肃兰州 730050;
3.西北民族大学,甘肃兰州 730030

收稿日期:2024-07-03 修回日期:2024-08-07 出版日期:2024-11-20 发布日期:2024-12-11
通讯作者: 杨艳丽,E-mail: a06974723@163.com
作者简介:郭小冬（1998-）,男,硕士,住院医师,E-mail: 1040624561@qq.com
基金资助:
甘肃省科技计划资助（省青年科技基金,22JR5RA022）; 中国人民解放军联勤保障部队第940医院院内课题（2021yxky049）

Ghost cell odontogenic carcinoma in the left maxilla: a case report and literature review

GUO Xiao-dong^1,2, SU Qin-jun², WANG Huan-huan^1,2, HE Qian-qian^1,2, CHEN Zhe-yu^2,3, JI Pu-zhong², MA Ying-chun², YANG Yan-li^1,2,3

1. Gansu University of Chinese Medicine. Lanzhou 730000;
2. Department of Pathology, The 940 Hospital of the Joint Logistics Support Force of the People's Liberation Army. Lanzhou 730050;
3. Northwest Minzu University. Lanzhou 730030, Gansu Province, China

Received:2024-07-03 Revised:2024-08-07 Online:2024-11-20 Published:2024-12-11

摘要/Abstract

摘要： 牙源性影细胞癌（ghost cell odontogenic carcinoma,GCOC）是起源于颌骨的罕见恶性肿瘤,其在临床与影像上可表现出与良性牙源性肿瘤不同的恶性特征,例如肿瘤体积大、伴有周围骨质破坏等,但不具备特异性,因此往往依靠病理形态学确诊。GCOC的特征在于异常角质化的影细胞、小的基底样细胞和类牙本质沉积。准确诊断该病有重要的临床意义并有利于患者预后。本文报告1例左侧上颌骨GCOC,并结合相关文献进行复习。

关键词: 上颌骨肿瘤, 牙源性肿瘤, 牙源性影细胞癌, 病理特征

Abstract: Ghost cell odontogenic carcinoma(GCOC) is a rare malignant tumor originating in the jawbone, which can exhibit clinically and radiographically malignant features distinct from benign odontogenic tumors, such as large tumor size and adjacent bone destruction, but these features lack specificity; therefore, diagnosis often relies on pathological morphology. Characterized by abnormal keratinized ghost cells, small basaloid cells, and dentin-like deposits, accurate identification of GCOC holds significant clinical importance and is beneficial for patient prognosis. This paper reported a case of GCOC in the left maxilla and reviewed the relevant literature.

Key words: Maxillary tumor, Odontogenic tumor, Ghost cell odontogenic carcinoma, Pathological feature

中图分类号:

R739.8

郭小冬, 苏勤军, 王环环, 何倩倩, 陈哲宇, 姬菩忠, 马迎春, 杨艳丽. 左侧上颌骨牙源性影细胞癌1例报告及文献复习[J]. 中国口腔颌面外科杂志, 2024, 22(6): 618-621.

GUO Xiao-dong, SU Qin-jun, WANG Huan-huan, HE Qian-qian, CHEN Zhe-yu, JI Pu-zhong, MA Ying-chun, YANG Yan-li. Ghost cell odontogenic carcinoma in the left maxilla: a case report and literature review[J]. China J Oral Maxillofac Surg, 2024, 22(6): 618-621.

参考文献

[1] Vijayakumar G, Kamboj M, Narwal A, et al.Ghost cell odontogenic carcinoma of anterior mandible: a rare case report with review of literature[J]. J Oral Maxillofac Pathol, 2021, 25(Suppl 1): S99-S108.
[2] De Arruda JAA, Monteiro J, Abreu LG, et al.Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: a systematic review[J]. J Oral Pathol Med, 2018, 47(8): 721-730.
[3] Ikemura K, Horie A, Tashiro H, et al.Simultaneous occurrence of a calcifying odontogenic cyst and its malignant transformation[J]. Cancer, 1985, 56(12): 2861-2864.
[4] Grodjesk JE, Dolinsky HB, Schneider LC, et al.Odontogenic ghost cell carcinoma[J]. Oral Surg Oral Med Oral Pathol, 1987, 63(5): 576-581.
[5] 郑怡, 苏立众, 徐加杰, 等. 数字化三维重建手术治疗上颌窦牙源性影细胞癌1例[J]. 中国耳鼻咽喉头颈外科, 2022, 29(8): 538-539.
Zheng Y, Su LZ, Xu JJ, et al.A case of odontogenic ghost cell carcinoma of the maxillary sinus was treated by digital three-dimensional reconstruction surgery[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2022, 29(8): 538-539.
[6] 裴超帅, 陈英敏, 郑学超, 等. 右侧上颌骨牙源性影细胞癌1例[J]. 中国医学影像学杂志, 2022, 30(11): 1123-1124.
Pei CS, Chen YM, Zheng XC, et al.A case report of odontogenic ghost cell carcinoma in the right maxilla[J]. Chinese Journal of Medical Imaging, 2022, 30(11): 1123-1124.
[7] Oliveira Santos P, Cabrera R, Vilares M, et al.Ghost cell odontogenic carcinoma of the left maxilla[J]. BMJ Case Rep, 2021, 14(4): e242445.
[8] Gomes da Silva W, Ribeiro Bartholomeu Dos Santos TC, Cabral MG, et al. Clinicopathologic analysis and syndecan-1 and Ki-67 expression in calcifying cystic odontogenic tumors, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(5): 626-633.
[9] Del Corso G, Tardio ML, Gissi DB, et al.Ki-67 and p53 expression in ghost cell odontogenic carcinoma: a case report and literature review[J]. Oral Maxillofac Surg, 2015, 19(1): 85-89.
[10] Rappaport MJ, Showell DL, Edenfield WJ.Metastatic ghost cell odontogenic carcinoma: description of a case and search for actionable targets[J]. Rare Tumors, 2015, 7(3): 5813.
[11] Oh KY.Beta-catenin nuclear translocation and WNT pathway mutations in ghost cell odontogenic carcinoma: a literature review and proposal of a new molecular-based classification "WNT pathway-altered malignant odontogenic tumor"[J]. Oral Oncol, 2024, 155: 106907.
[12] Conde DC, Vieira GS, Montovani PP, et al.Dentinogenic ghost cell tumor with focal atypical features suggesting ghost cell odontogenic carcinoma: report of a challenging diagnosis[J]. Oral Oncol, 2022, 124: 105524.
[13] Remya K, Sudha S, Nair RG, et al.An unusual presentation of ghost cell odontogenic carcinoma: a case report with review of literature[J]. Indian J Dent Res, 2018, 29(2): 238-243.
[14] Panprasit W, Lappanakokiat N, Kunmongkolwut S, et al.Ghost cell odontogenic carcinoma: a case report[J]. Imaging Sci Dent, 2021, 51(2): 203-208.
[15] Nel C, Robinson L, Van Heerden WFP.Ghost cell odontogenic carcinoma arising in the background of a calcifying odontogenic cyst[J]. Oral Radiol, 2021, 37(3): 537-542.
[16] Xia Y, Song Z, Zhang X, et al.Ghost cell odontogenic carcinoma: a rare case report and review of literature[J]. Medicine (Baltimore), 2023, 102(38): e35225.

左侧上颌骨牙源性影细胞癌1例报告及文献复习

Ghost cell odontogenic carcinoma in the left maxilla: a case report and literature review

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价

[1]	薛俊青, 张莺, 胡宇华, 李江, 夏荣辉. 三级淋巴结构与头颈部鳞癌临床病理特征及预后的相关性分析[J]. 中国口腔颌面外科杂志, 2024, 22(6): 541-546.
[2]	韩林孜, 房义康, 禹雯怡, 王奇民, 童磊, 邱建忠, 袁荣涛. 口腔乳头状唾液腺瘤1例临床病理分析[J]. 中国口腔颌面外科杂志, 2022, 20(1): 98-100.
[3]	蒋建磊, 代天国, 田卓炜, 王丽珍, 何悦. 口腔颌面-头颈部眶外巨细胞血管纤维瘤的临床及病理特征分析[J]. 中国口腔颌面外科杂志, 2015, 13(2): 161-166.
[4]	张国志;郑友丽;张国权. 骨外型牙源性钙化上皮瘤 [J]. 中国口腔颌面外科杂志, 2013, 11(3): 247-251.