EGFL7在血管生成调控中的研究进展

doi:10.19438/j.cjoms.2019.04.021

中国口腔颌面外科杂志 ›› 2019, Vol. 17 ›› Issue (4): 377-381.doi: 10.19438/j.cjoms.2019.04.021

EGFL7在血管生成调控中的研究进展

杜仲, 刘嘉靓, 郑家伟, 王延安

上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科, 国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2018-09-18 修回日期:2018-11-08 出版日期:2019-07-20 发布日期:2019-08-12
通讯作者: 王延安,E-mail：wangyan_an@163.com
作者简介:杜仲（1992-）,男,在读博士研究生,E-mail：duzhongd987@163.com
基金资助:
国家自然科学基金（81371164）

Current research progress of EGFL7 in angiogenesis regulation

DU Zhong, LIU Jia-liang, ZHENG Jia-wei, WANG Yan-an

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2018-09-18 Revised:2018-11-08 Online:2019-07-20 Published:2019-08-12

摘要/Abstract

摘要： 表皮生长因子结构域7（epidermal growth factor-like domain-containing protein,EGFL7）是一类主要由血管内皮细胞分泌的分子,在包括胚胎发育、创伤修复、肿瘤、心血管疾病、缺血性疾病、炎症等的血管生成中发挥重要作用。本文从血管生成调控的角度,对该蛋白的表达分布特点、相关动物模型研究、血管内皮细胞相关改变、分子调控机制等进行综述,以期为相关研究及治疗提供新的思路。

关键词: 表皮生长因子结构域7, 血管生成, 动物模型, NOTCH, 整合素

Abstract: Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in endothelial cells. The findings from present studies suggest that EGFL7 can influence different aspects related to the angiogenesis process, such as embryogenesis, tumorigenesis, wound healing, cardiovascular diseases, etc. From the point of angiogenesis regulation, we reviewed the expression profiles, animal models, endothelial phenotypes and molecular mechanisms of EGFL7, which would provide a novel insight into further researches or targeted therapies.

Key words: EGFL7, Angiogenesis, Animal model, NOTCH, Integrin

中图分类号:

R543

杜仲, 刘嘉靓, 郑家伟, 王延安. EGFL7在血管生成调控中的研究进展[J]. 中国口腔颌面外科杂志, 2019, 17(4): 377-381.

DU Zhong, LIU Jia-liang, ZHENG Jia-wei, WANG Yan-an. Current research progress of EGFL7 in angiogenesis regulation[J]. China J Oral Maxillofac Surg, 2019, 17(4): 377-381.

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EGFL7在血管生成调控中的研究进展

Current research progress of EGFL7 in angiogenesis regulation

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