焦亡及其与头颈部肿瘤关系的研究进展

doi:10.19438/j.cjoms.2019.01.018

摘要/Abstract

摘要： 细胞程序性死亡是指细胞依赖于某些特定的基因编码信号或活动的死亡方式。细胞凋亡、自噬、胀亡、焦亡等均属于细胞程序性死亡。其中,焦亡是一种依赖含半胱氨酸的天冬氨酸蛋白水解酶（caspase）的细胞程序性死亡方式。近年来,国内外相关研究发现,焦亡与炎性疾病、自身免疫性疾病及肿瘤均有关系。充分了解焦亡发生的机制及其与肿瘤的关系,对肿瘤的治疗具有一定的指导意义。本文针对焦亡的相关机制及焦亡与头颈部肿瘤的相关研究进展进行综述。

关键词: 焦亡, caspase, gasdermin, IL-1β, IL-18

Abstract: Programmed cell death refers to the way in which cells depend on certain genes to encode signals or activities. Apoptosis, autophagy, apoptosis and pyroptosis all belong to programmed cell death,pyroptosis is a programmed cell death dependent on cysteine containing aspartate proteinase (caspase) . Recently, many studies found that pyroptosis is associated with inflammatory diseases, autoimmune diseases and tumors. A thorough understanding of the mechanism of pyroptosis and its relationship with tumors is of guiding significance in the treatment of tumors. This article focus on the mechanism of pyroptosis and the related research progress of pyroptosis and tumor of head and neck.

Key words: Pyroptosis, Caspase, Gasdermin, IL-1β, IL-18

中图分类号:

R739.8

张骞予, 黄志权. 焦亡及其与头颈部肿瘤关系的研究进展[J]. 中国口腔颌面外科杂志, 2019, 17(1): 86-92.

ZHANG Qian-yu, HUANG Zhi-quan. Research progress on pyroptosis and relationship between pyroptosis and tumor of head and neck[J]. China J Oral Maxillofac Surg, 2019, 17(1): 86-92.

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