中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (1): 23-27.doi: 10.19438/j.cjoms.2026.01.004

• 论著 • 上一篇    下一篇

中性粒细胞与血小板比值在腮腺恶性肿瘤中的诊断价值

薛星月1,2, 曹焜2, 卢芳2, 鲍强2, 孙玉华2, 李家锋2   

  1. 1.徐州医科大学口腔医学院,江苏 徐州 221004;
    2.徐州医科大学附属医院 口腔科,江苏 徐州 221006
  • 收稿日期:2025-03-24 修回日期:2025-05-24 发布日期:2026-02-06
  • 通讯作者: 李家锋,E-mail：jiafengli203@163.com
  • 作者简介:薛星月（2000-）,女,在读硕士研究生,E-mail：13063516765@163.com
  • 基金资助:
    徐州医科大学附属医院科技发展基金面上项目（XYFM202403）

Predictive value of preoperative neutrophil to platelet ratio in the diagnosis of parotid malignant tumors

Xue Xingyue1,2, Cao Kun2, Lu Fang2, Bao Qiang2, Sun Yuhua2, Li Jiafeng2   

  1. 1. School of Stomatology, Xuzhou Medical University. Xuzhou 221004;
    2. Department of Stomatology, Affiliated Hospital of Xuzhou Medical University. Xuzhou 221006, Jiangsu Province, China
  • Received:2025-03-24 Revised:2025-05-24 Published:2026-02-06

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摘要： 目的: 探讨术前中性粒细胞与血小板比值（NPR）在腮腺恶性肿瘤中的诊断价值,分析其与肿瘤分期及淋巴结转移的相关性。方法: 选择2022 年10月—2024年10月徐州医科大学附属医院收治的腮腺肿瘤患者248例,其中恶性肿瘤组（试验组）124例,良性肿瘤组（对照组）124 例。比较两组患者术前外周血NPR、中性粒细胞与淋巴细胞比值（NLR）、全身炎症反应指数（SIRI）等炎症指标,通过logistic回归分析筛选腮腺恶性肿瘤的独立危险因素,采用受试者工作特征（ROC）曲线评估NPR的诊断效能。结果: 试验组NPR水平显著高于对照组（P<0.001）。多因素logistic 回归显示,NPR是腮腺恶性肿瘤的独立危险因素（OR=1.055,95%CI：1.007~1.104,P=0.022）。试验组中,淋巴结转移组NPR显著高于非转移组（P<0.001）,晚期组（Ⅲ+Ⅳ 期）显著高于早期组（Ⅰ+Ⅱ 期）（P<0.05）。ROC曲线显示,NPR诊断腮腺恶性肿瘤的曲线下面积（AUC）为0.663（95%CI：0.587~0.739）,在最佳临界值0.014时,敏感度为68.8%,特异度为58.3%。结论: 术前外周静脉血NPR水平可作为腮腺恶性肿瘤的辅助诊断指标,高NPR提示肿瘤恶性风险高、分期晚且淋巴结转移可能性大,但其诊断效能有限,需结合临床检查综合判断。

关键词: 腮腺恶性肿瘤, 中性粒细胞与血小板比值, 炎症反应, 诊断价值, 淋巴结转移

Abstract: PURPOSE: To explore the diagnostic value of preoperative neutrophil-to-platelet ratio(NPR) in malignant parotid tumors, and to analyze its correlation with tumor stage and lymph node metastasis. METHODS: A total of 248 patients with parotid tumors admitted to Affiliated Hospital of Xuzhou Medical University from October 2022 to October 2024 were selected, including 124 cases in the malignant tumor group (experimental group) and 124 cases in the benign tumor group (control group). Inflammatory indicators such as preoperative peripheral blood NPR, neutrophil-to-lymphocyte ratio (NLR), and systemic inflammatory response index (SIRI) were compared between the two groups. Logistic regression analysis was used to screen independent risk factors for malignant parotid tumors, and receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic efficacy of NPR. RESULTS: The level of NPR in the experimental group was significantly higher than that in the control group(P<0.001). Multivariate logistic regression showed that NPR was an independent risk factor for malignant parotid tumors(OR=1.055, 95%CI: 1.007-1.104, P=0.022). In the experimental group, NPR in the lymph node metastasis group was significantly higher than that in the non-metastasis group(P<0.001), and NPR in the advanced stage group(stage Ⅲ + Ⅳ) was significantly higher than that in the early stage group (stage Ⅰ+Ⅱ)(P<0.05). The ROC curve showed that the area under the curve(AUC) of NPR for diagnosing malignant parotid tumors was 0.663(95%CI: 0.587-0.739). At the optimal cut-off value of 0.014, the sensitivity was 68.8% and the specificity was 58.3%. CONCLUSIONS: The level of preoperative peripheral venous blood NPR can be used as an auxiliary diagnostic indicator for malignant parotid tumors. A high NPR indicates a high risk of malignant tumors, advanced stage, and a high possibility of lymph node metastasis. However, its diagnostic efficacy is limited and needs to be comprehensively judged in combination with clinical examination.

Key words: Malignant parotid tumor, Neutrophil-to-platelet ratio, Inflammatory response, Diagnostic value, Lymph node metastasis

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