胶原膜在引导骨再生技术中的应用和改良研究进展

doi:10.19438/j.cjoms.2023.06.014

摘要/Abstract

摘要： 胶原蛋白是哺乳动物体内最丰富的蛋白质,将其作为主要材料制成的生物膜具有良好的理化性质和生物学功能,被广泛用于骨组织工程等医学领域。在引导骨再生技术中,以胶原膜作为可吸收屏障膜被广泛应用,但仍存在降解不可控、机械强度低等缺陷。为了改进这些不足,通过交联、矿化、表面修饰等方法,新型胶原膜的不断开发和应用成为该领域未来的发展趋势。本文就胶原膜在引导骨再生技术中的应用和改良进行综述,以期为新型胶原膜的研发提供新的思路。

关键词: 引导骨再生, 胶原膜, 交联, 复合材料

Abstract: Collagen is the most abundant protein in mammals. Biomembrane made of collagen as the main material has good physicochemical properties and biological activities, which is widely used in bone tissue engineering and other medical fields. In terms of guided bone regeneration (GBR), the collagen membrane has a broad scope in its clinical application as a barrier membrane, but still has disadvantages such as uncontrolled degradation, low mechanical strength, etc. In order to improve these shortcomings, the continuous development of new collagen membranes through cross-linking, mineralization, and surface modification has become the future development trend in this field. In this paper, the application and modification of collagen membrane in GBR was reviewed to provide novel insights into the research and development of new membranes.

Key words: Guided bone regeneration, Collagen membrane, Cross-link, Composites

中图分类号:

R782

顾安琪, 周文洁, 王跃平. 胶原膜在引导骨再生技术中的应用和改良研究进展[J]. 中国口腔颌面外科杂志, 2023, 21(6): 615-620.

GU An-qi, ZHOU Wen-jie, WANG Yue-ping. Application and modification of collagen membrane in guided bone regeneration techniques[J]. China J Oral Maxillofac Surg, 2023, 21(6): 615-620.

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