中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2019, Vol. 17 ›› Issue (5): 436-439.doi: 10.19438/j.cjoms.2019.05.009

• 论著 • 上一篇    下一篇

新疆喀什地区非综合征型唇腭裂发病危险因素的病例对照研究

阿力木江·苏甫尔, 比力克孜·玉素甫, 热娜古孜·阿不都米吉提   

  1. 喀什地区第一人民医院 口腔颌面外科,新疆 喀什 844000
  • 收稿日期:2019-03-28 出版日期:2019-09-20 发布日期:2020-03-11
  • 通讯作者: 比力克孜·玉素甫,E-mail：3414067817@qq.com
  • 作者简介:阿力木江·苏甫尔（1984-）,硕士,主治医师,E-mail：1667730023@qq.com
  • 基金资助:
    喀什地区科技计划项目（KS2017035,KS2017036）

A case-control study on the risk factors of patients with non-syndromic cleft lip and palate in Kashgar area of Xinjiang Uygur Autonomous Region

ALIMUJIANG Sufuer, BILIKEZI Yusufu, RENAGUZI Abudumijiti   

  1. Department of Oral and Maxillofacial Surgery, the First People's Hospital of Kashgar. Kashgar 844000, Xinjiang Uygur Autonomous Region, China
  • Received:2019-03-28 Online:2019-09-20 Published:2020-03-11

摘要： 目的：探讨新疆喀什地区非综合征型唇腭裂（NSCL/P）发病的相关危险因素。方法：采用病例对照研究方法,纳入102例NSCL/P患儿,204例正常儿童。对研究对象进行问卷调查,内容包括孕妇基本情况、围产儿基本情况、孕妇孕前至孕期情况等。采用SPSS 17.0软件包进行危险因素的单因素、多因素 Logistic 回归分析。结果：唇腭裂家族史、近亲结婚、孕早期用药、孕早期接触农药及化学药品、孕期营养及健康状况差、孕早期精神状况差是喀什地区NSCL/P的危险因素（P<0.05）,口服叶酸片为保护因素（P<0.05）。结论：孕期普及口服叶酸片、避免乱用药及接触危险化学药品、改善孕妇营养及健康状况、避免近亲结婚对降低NSCL/P的发生具有重要意义。

关键词: 新疆喀什地区, 非综合征型唇腭裂, 危险因素

Abstract: PURPOSE: To investigate the risk factors of non-syndromic cleft lip with or without cleft palate (NSCL/P) in Kashgar area of Xinjiang Uygur Autonomous Region. METHODS: This case-control study involved 102 NSCL/P patients and 204 normal children from Kashgar area. A questionnaire focusing on various possible risk factors, and responses were analyzed through univariate and multivariate Logistic regression with SPSS 17.0 software package. RESULTS: Logistic regression analysis revealed that family history, consanguineous marriage, drugs, sickness and malnutrition in early pregnancy, contact with pesticides, chemicals, poor mental state increased the risk of NSCL/P(P<0.05). Folic acid supplementation decreased the risk of NSCL/P(P<0.05). CONCLUSIONS: Taking sufficient folic acid, avoiding consanguineous marriage, avoiding contact with pesticides and chemicals, improving health and nutritional status during early pregnancy may decrease the birth rate of NSCL/P in Kashgar area of Xinjiang Uygur Autonomous Region.

Key words: Kashgar area, NSCL/P, Risk factors

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