微小RNA对成骨调控作用的研究进展

中国口腔颌面外科杂志 ›› 2015, Vol. 13 ›› Issue (1): 85-89.

微小RNA对成骨调控作用的研究进展

王凤¹, 邹多宏², 吴轶群¹

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔种植科,上海 200011; 2.安徽医科大学口腔医学院,安徽医科大学附属口腔医院牙种植中心,安徽省口腔疾病研究中心实验室,安徽合肥,230032

收稿日期:2014-09-04 出版日期:2015-02-10 发布日期:2015-03-12
通讯作者: 吴轶群,Tel:021-23271699-5299,E-mail:yiqunwu@hotmail.com E-mail:diana_wangfeng@hotmail.com
作者简介:王凤（1981-）,女,博士研究生,主治医师

Research advances of microRNA in osteogenesis regulation

WANG Feng¹, ZOU Duo-hong², WU Yi-qun¹

1. Department of Oral Implantology, Ninth People′s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011; 2. Dental Implant Center of Stomatological Hospital ﹠College, Anhui Medical University, Key Lab of Oral Diseases Research of Anhui Province. Hefei 230032, Anhui Province, China

Received:2014-09-04 Online:2015-02-10 Published:2015-03-12
About author:Supported by National Natural Science Foundation of China (81371190) and Natural Science Foundation of Shanghai Municipality (13ZR1424000)
Supported by:
国家自然科学基金（81371190）; 上海市自然科学基金（13ZR1424000)

摘要/Abstract

摘要： ] 成骨细胞的分化和功能调控需由体内多种激素和局部产生的细胞因子协同完成。miRNAs (microRNAs) 是单股非编码的 RNAs 小分子,长度在 20~24个核苷酸大小。它通过与目标 RNA 基因的特定序列结合,参与基因转录后水平的调控。研究表明,miRNA 能够调控成骨细胞、破骨细胞和软骨细胞的增殖和分化,维持骨形成和骨吸收的平衡,调控软骨的骨化,是生物器官发育和某些骨代谢疾病的重要调控因子。miRNA 的发现, 揭示了基因组非编码区域蕴涵着重要的功能。因此,利用 miRNA治疗临床骨代谢疾病和修复骨缺损具有潜在的临床应用前景。本文对 miRNA 在骨形成过程中的调控作用及其研究进展作一综述。

关键词: 微小RNA, 调控, 骨形成

Abstract: The differentiation and function regulation of osteoblast rely on the co-operation between various hormones and cytokines which are locally produced. micro-RNAs (miRNAs) are single strand and non-coding RNAs which comprise 20 to 24 nucleotides in length. They are involved in the regulation of post-transcriptional events through combination of specific sequence on target RNA gene. Current literatures indicate that miRNAs can regulate the differentiation and proliferation of osteoblast, osteoclast and cartilage, and maintain the balance between bone formation and bone absorption. They also regulate the ossification of cartilage. Therefore, miRNAs are powerful regulators for biological organ development and some metabolic bone diseases. The discovery of miRNAs shows an important function containing in the noncoding region of genome. They are expected to provide potential gene therapy targets for clinical treatment of metabolic bone diseases and recovery of bone defect. This review summarized the current understanding and progress of microRNAs in osteogenesis regulation.

Key words: miRNA, Regulation, Osteogenesis

中图分类号:

王凤, 邹多宏, 吴轶群. 微小RNA对成骨调控作用的研究进展[J]. 中国口腔颌面外科杂志, 2015, 13(1): 85-89.

WANG Feng, ZOU Duo-hong, WU Yi-qun. Research advances of microRNA in osteogenesis regulation[J]. China J Oral Maxillofac Surg, 2015, 13(1): 85-89.

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